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OUR TEAM: UZURICH

UZurich 2022: The official iGEM team of the University of Zurich

IBD NanoBiotics

Inflammatory Bowel Disease (IBD) is an umbrella term that comprises conditions such as Crohn’s disease (CD) and ulcerative colitis (UC). Patients suffer from chronic inflammation in the gastrointestinal tract that leads to symptoms like bloody stools, diarrhea, abdominal pain, and fatigue. As of today, the cause of IBD is still unknown and there is no cure available. Current therapies are systemic and can lead to severe side effects. Furthermore, the therapies’ costs are causing a significant economic burden on the national health care system. We, the 2022 iGEM team from the University of Zurich, want to tackle the lack of targeted treatment options by harnessing the power of the gut microbiome to help IBD patients and increase their daily quality of life. On our mission, we have divided ourselves into three groups to build the fundamental pillars of our project.

Every iGEM team additionally will maintain a website that contains all the information about their project which will go online towards the end of their project.

If you have questions or are interested in their project, check out their instagram and or feel free to contact them via email at igemteamuzh@gmail.com!

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PREVIOUS TEAMS

Want to know what previous teams at UZH did?

UZURICH 2021

Plants are the basis of sustenance. Human beings need food to live. The world population is growing. All these aspects have a central hinge: food stability. Synthetic pesticides have so far tried to play this role, but their limitations are increasingly evident: loss of biodiversity, human health problems, development of resistance by the pathogens attacked. We have the solution: Outer Membrane Vesicles. OMVs are bubbles that can do what a vaccine does for people, give a boost to their immune defences, therefore ensuring a stable future for agriculture.

UZURICH 2020

It is our mission to elaborate on the implementation of plant PRRs (pattern recognition receptors). These membrane located proteins offer potential for microbial load detection in water. By collaborating with industry and academia alike, we are advancing the broad field of plant immunity and bio-reporters.

UZURICH 2019

We took a step towards constructing a large protein cage within bacteria that can be used to confine and compartmentalize biochemical reactions with potential toxic intermediate products.

To produce this protein cage, we took a minimal component approach to replicate a natural phage-bacteria interaction. The phage we worked with encapsulates its DNA into a protein cage upon infection of the host bacteria.

By using multiple approaches such as microscopy, sequence analysis and in-vitro assays, we started to assess which proteins are necessary to form this protein cage. We then co-expressed promising candidate genes in the host and evaluated the results via microscopy.

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Check out what UZURICH 2021 did:

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Check out what UZURICH 2020 did:

Our team: About My Project